Django is available as an EPEL package.
First, activate EPEL via
$ sudo rpm -Uvh http://dl.fedoraproject.org/pub/epel/6/x86_64/epel-release-6-8.noarch.rpm
or for 32-bin CentOS,
$ sudo rpm -Uvh http://download.fedoraproject.org/pub/epel/6/i386/epel-release-6-8.noarch.rpm
NOTE: That exact URL will change with time. I took it from the EPEL FAQ.
Next, install the Django package.
$ sudo rpm install Django
Ensure that Django is working.
$ python Python 2.6.6. (r266:84292, Feb 22 2013, 00:00:18) [GCC 4.4.7 20120313 (Red Hat 4.4.7-3)] on linux2 Type "help", "copyright", "credits" or license" for more informaiton. >>> import django >>> print django.get_version() 1.4.5 >>> _